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Gather your ingredients!

Whisk ketchup, garlic powder, vinegar, and brown sugar together in a bowl.

Whisk in 2 tbsp Worcestershire sauce.

Sprinkle half the salt & pepper over each side of trimmed brisket.

Pat to make salt & pepper "stick"

Place brisket in crock pot & pour mixture over the top.

Spread onion over the brisket.

Cover and cook on low for 6 hours.

Remove brisket from crock pot. Let sit for a couple minutes, then slice against the grain. Serve with juices spread over the top. Delicious!